Quick Answer: Is Topamax metabolized by the liver?

Is Topamax toxic to liver?

Topiramate is thought to be rarely associated with liver injury and by and large known to cause liver toxicity in conjunction with other anticonvulsants.

Does topiramate affect liver function?

(Review of results of clinical trials of topiramate; most common side effects were CNS symptoms such as dizziness and somnolence; “There have been no cases of severe liver dysfunction or damage from topiramate”).

How is Topamax metabolized?

Topiramate is not extensively metabolized and is primarily eliminated unchanged in the urine (approximately 70% of an administered dose). Six metabolites have been identified in humans, none of which constitutes more than 5% of an administered dose.

What are the long term effects of taking Topamax?

Long-term side effects of Topamax

Most Topamax side effects aren’t permanent, and go away with time. For example, fatigue (low energy) and feelings of burning or numbness in your hands and feet may go away as you continue taking Topamax.

Can topiramate cause liver failure?

Fulminant liver failure occurred after a dose increase of topiramate and may have been due to topiramate alone or to an interaction with carbamazepine. We recommended the monitoring of liver function during treatment with topiramate, especially after dose increases.

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Is topiramate a liver enzyme inducer?

Topiramate is a liver enzyme inducing medication. (1) There is limited information available on interactions between topiramate and hormonal contraception. Two studies have investigated the effect of topiramate on a combined oral contraceptive containing 35mcg of ethinyl estradiol and 1 mg norethisterone.

Is there a lawsuit against Topamax?

Lawsuits blame Janssen Pharmaceuticals Inc. for birth defects in babies born to women who took Topamax while pregnant. Claims include Janssen’s failure to warn women and their doctors about the drug’s risks. The U.S. Department of Justice has also accused Janssen of illegally promoting Topamax for off-label uses.

Why should I take Topamax at night?

Taking Topamax can make you very drowsy and even dizzy. You should avoid driving, using heavy machinery, or doing other tasks that require alertness until you know how this medication affects you. Because it can cause drowsiness, Topamax is often taken at night.

What causes liver toxicity?

Toxic hepatitis is an inflammation of your liver in reaction to certain substances to which you’re exposed. Toxic hepatitis can be caused by alcohol, chemicals, drugs or nutritional supplements. In some cases, toxic hepatitis develops within hours or days of exposure to a toxin.

Is topiramate a GABA agonist?

While its precise mechanism of action is unknown, topiramate may block sodium-channels, and act as a GABAA receptor agonist and an excitatory amino acid receptor antagonist Reis et al (2002). Its side effects include ataxia, drowsiness, psychomotor slowing, nausea, decreased concentration, and speech problems.

How is zonisamide metabolized?

Zonisamide is metabolized by the liver and eliminated by the kidneys; caution should therefore be exercised when administering ZONEGRAN to patients with hepatic and renal dysfunction (see CLINICAL PHARMACOLOGY, Special Populations subsection).

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Does Topamax increase GABA?

Conclusion: This study demonstrates that single doses of topiramate and gabapentin increase cerebral GABA concentrations acutely (hours) in healthy individuals, but all drugs at clinically utilized doses increase cerebral GABA at 4 weeks.

How long can you stay on Topamax?

You can usually stay on Topamax (topiramate) to help prevent your migraine headaches as long as treatment is needed and remains safe for you. You and your doctor will decide how long you stay on treatment. This will be based on how well it is working for you and any side effects you may experience.

Does topiramate cause permanent brain damage?

An open study examined the behavioral and cognitive effects of topiramate as add-on treatment in children and adolescents with mild to severe mental retardation [Coppola et al. 2008]. The authors reported a significant cognitive deterioration in about 70% of patients at 3 months, persisting in about 20% at 12 months.

Why can’t I taste carbonation on Topamax?

Topiramate not uncommonly causes weight loss, and the degree of weight reduction tends to correlate with dose and duration of therapy. Finally, the drug may cause carbonated beverages to taste “flat.”